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Integrating Detoxification and Metabolic Clarity to Build Vital Immunity

October 3, 2020 @ 10:00 am - 4:30 pm

4 CE Credit Hours APPROVED for naturopaths and chiropractors virtually nationwide!


Presenter:  Christopher Shade, PhD


Course desciption:

The strength and resiliency of the immune system is more important than ever as we continue to navigate global-reaching environmental threats, however depth of immune function is crucially hinged on keeping toxin loads low and metabolic function high (metabolic clarity). Traditionally integrative and functional medicine has had high regard for detoxification, but a low mechanistic understanding of its function and its clear overlap with metabolic clarity.  Key to these functions is the liver, which under poor conditions 1) does not pass toxins into the bile and onto the GI tract (blocked directionality) leading to toxicity, and 2) does not properly regulate metabolism (e.g. insulin sensitivity), leading to metabolic syndromes.  The toxicity and metabolic dysregulation together lead to lowered cellular energy due to depleted mitochondrial function.  Endotoxemia features strongly in altering proper function of the liver, but dietary aspects such as carbohydrate excess and phytochemical deficiency play strongly as well.

This seminar will focus on pathways from cell to excretion, the overlap of metabolic factors that promote autophagy (self-eating) and renewal, build mitochondrial and NAD+ pools, and correct patterns of metabolic dysfunctions.

Learning Objectives:

  • Understand the Phases of Detoxification and their connection to Nrf2 activation
  • Understand potential liver pathways
  • Understand the effects of inflammation on detoxification pathways
  • Understand how the metabolic and autophagy benefits AMPK activation via supplementation coupled to keto diets or fasting accelerates and deepens benefits of detoxification
  • Understand how AMPK activation further increases cellular energy through augmentation of mitochondrial and NAD+ pools
  • Understand how to put together detoxification protocols that couple detox phase upregulation and metabolic activation

Hour 1 – Toxins, Toxicity, and the variable chemoprotective system: how detoxification pathways are dynamically regulated and intertwined with dietary and metabolic factors.

Hour 2 – The Phases of Detoxification within the inducible network of the chemoprotective system.  This includes cellular and systemic aspects of detoxification and their blockage by inflammagens such as endotoxin (LPS), including the crucial liver-bile-GI directionality.

Hour 3 – Autophagy and Metabolic Clarity: How AMPK activation coupled to dietary modification leads to the deepest levels of detoxification through renewal of damaged tissues, the release of fat-soluble toxins, and the augmentation of cellular NAD+ pools.

Hour 4 – Practical Detoxification: How to put together accurately designed elements of therapeutic systems to couple cellular detoxification to systemic toxin drainage.

Hour 5-6 – Clinical Application




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